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873 The expression of ACSL4 and 4-HNE increase in the cartilage of OA patients and OA mice, while metformin increases p-AMPK and p-ACC levels in IL-1β-treated chondrocytes, reverses ACSL4 and 4-HNE positive chondrocytes and OA lesions, and improves the ferroptosis sensitivity of chondrocytes through the AMPK/ACC pathway

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Tocopherols contain an aromatic ring with a hydroxyl that can donate H + to reduce FRs and a hydrophobic side chain able to penetrate into biological membranes [57] (Table 1)